Patch pump is finally here

January 2, 2010

The Melbourne, Australia based company Phosphagenics have finally annouced the first set of human trials for its TPM/insulin patch pump.

Ina press release published by the company, they indicate that a human trial has already completed proving the basic technology can deliver insulin to people with Type 1 diabetes.

According to Dr Esra Ogru, COO, the ability of the Phosphagenics’ TPM technology to deliver large proteins, such as insulin, through the skin and into the blood stream “has potential to reduce the number of invasive injections per day,” she said. “Our aim is to provide a basal level of insulin to people with diabetes over a sustained period. Currently basal levels of insulin are provided by injections. Basal insulin is the fastest growing segment of the insulin market.”

I can only hope that this time we actually get beyond the research and into a final product. We seem to have heard too many times that this type of technology is about to get into the market but we are still waiting.

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My diabetes travel supplies

December 18, 2009

Yesterday I was packing my diabetes supplies for an upcoming international trip, and though it may be useful to share some insights about what I’m packing. This is my first big trip since I’m on the pump, and must admit that my first impression is that there us a lot more “stuff” I need to carry with me compared with my last trip on injections. My kit looks like this:

Here is the list of what I’m bringing with me:

  • 2 boxes of Paradigm Quicksets (20 sets total)
  • 2 boxes of Paradigm reservoirs (20 in total)
  • 4 boxes of test strips for my Freestyle Lite(400 strips total)
  • Spare Medtronic pump
  • Portable sharps container
  • 3 vials of NovoRapid/Novolog (10ml each)
  • A few lancets
  • 5 syringes (in case things o wrong)
  • 3 AAA bateries + coin (for the pump)
  • Spare Freestyle Lite
  • Alcohol swabs
  • Ketone strips
  • Quickserter
  • Frio bag (to keep the insulin

Overall, my diabetes supplies will take about half of the space on my carry-on, and believe me, I want this stuff with me at all times. The last thing I want is for my diabetes supplies to be lost in one of the many connections I need to take,  so puting it in checked luggage is not going to be an option.

It’s probably also worth mentioning (you probably noticed in the list above) that I’m taking a second insulin pump with me. Medtronic has a program where you can get a spare pump when you are traveling. It’s probably not necesary if your destination is in a country where Medtronic has a significant presence. However if your trip includes more obscure places I highly recommend you consider borrowing a backup. My backup pump is Medtronic 515, a bit older than my current Medtronic 522, but considering is just a backup, it should be more than adequate. Kudos to Medtronic for puting this program in in place here in Australia.

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The latest innovation on the insulin market

December 8, 2009

Today I received a press release from Lilly about their latest innovation on insulin… 3ml vials… yep… I’m not kidding…

Over the last few years, Lilly has fell behind in the area of type 1 diabetes care. After the introduction of Humalog in 1996 we are yet to see any new significant advancements from the American giant.

The last few attempts have been really disappointing. First, the introduction of the Kwikpen, which although interetsing, only replicates what NovoNordisk and Sanofi-Aventis had already done with their isulins.

And then there was the issue with the discontinuation of Ultralente. Lilly discontinued four of their very old products because there was not enough demand for them anymore. However, they did not replace them with newer products. One can only speculate on whether this was triggered by the success of what is possibly the biggest insulin seller of all times… Lantus.

It’s always sad to see reduction of competition on the diabetes market, because competition is a key driver for innovation, better products and ultimately better care.  Lilly’s position is only a confirmation of the sad reality of diabetes drugs… it’s about business.

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How to make sense of Diabetes

November 27, 2009

A couple of days ago I bumped into a video produced by the guys at Tu Diabetes, and I thought it was too good not to give it a plug.  The video is a compilation of submissions by members of the Tu Diabetes community, and while humorous, shows the serious ways in which type 1 diabetes affects each of us.

According to DHF, the video was made “to raise diabetes awareness and in preparation for World Diabetes Day”. “We held the Making Sense of Diabetes video contest during October 2009. We sought video entries about the impact diabetes has on our lives through one of the five senses: sight, hearing, taste, touch and smell. We produced compilation video, showcasing footage from some of the videos for each of the senses.”

Here is the final compilation

Thanks to Manny and his team for organizing the contest and to all contributing members for their submissions.


Good news: Complications for Type 1 are decreasing

September 23, 2009

retinaAn article published in August by the Juvenile Diabetes Research Foundation has brought great news for those of us living with the big D.

According to the study “Thirty years of data from international trials show that the rate of serious complications amongst people with type 1 diabetes is lower that was has been reported historically.”

In another article published in a diabetes journal, it was reported that the main decline has been in mortality, renal failure and neuropathy. On the other hand overt nephropathy and proliferative retinopathy do not seem to be showing such positive signs.

The other odd issue in the report is around cardio vascular disease. The researchers observed a reduction in incidence in people who have had diabetes for 20 years, but this reduction seems to disappear in those who have lived with teh condition for more than 25 years

While a lot of this reduction seem to be driven by the adoption of intensive management, there is also significant progress coming from the development and use of new technologies including insulin pumps.

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A cure for Diabetes may be closer than ever

September 14, 2009

bayhill-300x93Many of my readers know that over the last 12 month I’ve been participating in a clinical trial for a new drug called BHT-3021.

According to the manufacturer, “BHT-3021 is a plasmid encoding proinsulin designed to tolerize the immune system to proinsulin, thereby turning off the self directed immune attack. This product candidate’s potential to improve glucose control could reduce or eliminate insulin dependence and long-term complications of T1D, which would address a major unmet need and capitalize on a significant commercial market opportunity”. In plain words, the drug is meant to help your immune system get used to pancreatic cells, and potentially stop the autoinmune disease.

After 12 weeks of participating in the trial, my insulin requirements started to go up, so I wasn’t very positive about the whole thing. In the last couple of weeks I’ve received a three pieces of news that have refreshed my optimism.

I received the first (and personally most important) piece of information when my trial results were unblinded a couple of weeks ago. As it turns out, I was initially given the placebo and not the active drug. What this means for me is that my personal experience is not really indicative of the effectivenesss of the drug.

I have also seen some of the preliminary study data, and it looks like the drug does indeed slow down the immune attack, which means that the drug may be effective after all. According to the study, “In the current phase I/II trial, patients receiving BHT-3021 demonstrated preservation of C-peptide and an acceptable safety profile.”

Lastly, there is the news about the partnership between Bayhill Therapeutics (the drug developer) and Genentech (part of the Roche group) for the commercialization of the drug. This is a huge endorsement and means that there is a serious interest in the drug.

I’ve now been offerend the active drug at the optimun dose, so I will keep updating my experience with the trial. Let’s hope that this is the breaktrhough we’ve been hoping for.

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Australian environment linked to type 1

August 21, 2009

diabetes-environmental-factors-insulinAccording to an article published today by the Herald Sun, the number of  Australian children developing Type 1 diabetes is growing by around four per cent each year, putting the country in the top 10 countries in the world in terms of the number of new cases. Figures released today show there were 987 new cases of insulin-dependent diabetes in children aged under 14 in 2007, compared with 758 in 2000.

This trend may be also replicated in Europe wherescientifics estimate that the total number of children under age 15 with type 1 diabetes will rise 70 percent to 160,000 by 2020, up from 94,000 now. To predict the future burden of type 1 diabetes,  Dr. Chris Patterson of Queen’s University in Belfast, Gyula Soltesz of Pecs University in Hungary and colleagues analyzed data from 17 European countries on 29,311 cases of type 1 diabetes during 1989 to 2003.

“These findings suggest that the incidence of type 1 diabetes is increasing even faster than before, pointing toward harmful changes in the environment in which contemporary children live,” Dr. Dana Dabelea of the University of Colorado in Denver wrote in a commentary.

For a while, there has been speculation about the causes of Type 1 diabetes, and in particular, whether genetic makeup or the environment are the triggers. Now there seems to be more evidence that the environment is playing a bigger role. Associate Professor Maria Craig, a paediatrician who specialises in diabetes at the University of NSW, says the rapid rise in Type 1 cases “means it’s got to be something in the environment because genes can’t change that quickly”.

In my personal conversations with various diabetes professionals the view seems to be that we simply may be getting better at diagnosing these cases, and not that there are more of them. There is also the question that now people with Type 1 diabetes can have children, which may inevitably spread whatever genetic factors are involved.

We obviously still have a lort or research to do before we can come any close to understanding what is causing type 1 diabetes.

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Is this the end of Diabetes Australia?

August 10, 2009

DART LogoDiabetes Australia is a national non for profit organization that deals with all types of Diabetes. You could think of it as the equivalent (although unrelated) to the American Diabetes Association here in Australia. More importantly for people with D, this organisation is in charge of administering the National Diabetes Services Scheme (NDSS) that provides subsidized testing strips and other consumables.

Like many of its international counterparts, Diabetes Australia is organized in chapters or member organizations, usually one per every state. An interesting tension has always existed amongst different member organizations over issues such as branding and spending priorities. It seems now the issue has become too big and half the state branches have now split.

Accoording to a report published in the Brisbane Times, “the national organisation has been plunged into disarray with a walkout by the NSW, South Australia and Northern Territory branches and the resignation of the national president, Gary Deed, and the chief executive, Matt O’Brien, in recent days.”

The three organisations have said that “they would welcome the establishment of a new body to replace the national organisation.”

So, is this the end of Diabetes Australia? How will Australians with D be able to maintain access to the NDSS which provides $750million of funding over the next 3 years? How will the lack of a national representing body affect the care and advocacy of Diabetes in Australia?


Medtronic involved in research fraud scandal

July 22, 2009

moneyforeheadLast week the Wall Street Journal published an article on the doctor who is currently being investigated for falsifying data on a study for one of Medtronic’s products. While the issue is not related to their Diabetes division, one could not avoid to think the implications this may have on the biggest manufacturer of insulin pumps.

The issue is related to a former Army surgeon, Dr. Timothy R. Kuklo, who alledgedly reported that a bone-growth product sold by Medtronic had much higher success than other doctors had experienced. According to reports, there are also documents that show that Medtronic may have financially supported Kuklo’s research.

According to reports published on Fierce Health, Medtronic has also made payments of almost $6 million in consulting fees, with some surgeons being paid in the high six figures in a single year. Medtronic, for its part, isn’t denying that it’s made consulting payments, but says that the payments weren’t kickbacks. Instead, it says, it paid doctors a legitimate fee to assist the company in determining how its devices could be best designed and used.

This event raises a broader issue that it’s not nearly as discussed as it should be, and is thequestion of whether companies get into the Diabetes market to do good, to get rich or just for glory. Diabetes is a growing illness, and inevitably attracts a lot of investment as there is a lot of money to be made. Whether the motivation is to finally find a cure or just to keep us alive and paying is the big questions.

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Type 1 Diabetes in the Developing World

July 9, 2009

diabetes-environmental-factors-insulinMany of you already know I’m not a native Australian. I was born in a little corner of South America in front of the Caribean. A beutiful country unfortunately plagged with many of the problems of the developing world.

I’m extremely lucky for a number of reasons. In the diabetes side of things, I was diagnosed as an adult, which means that I didn;t have to deal with the extra burden or growing up with D. More importantly, I was diagnosed here in Australia, were we have an advanced health system.

Not everyone is as lucky as I am.  There are 84 million people with Diabetes in the developing world, and this number is expected to increase to 228 million by 2030. Unfortunately, these people are the ones that have less resources available to manage the condition. The health system in most developing countries is also in much poorer shape.

ecuadorsmThere is a number of organisations trying to improve the lifes of people with Type 1 diabetes in  developing countries. my favourite is Insulin for Life a not-for-profit organisation that collects and distributes insulin and other diabetes supplies that would otherwise be wasted. This supplies are then distributed to places like Bolivia, Ecuador, Kosovo, Zimbawe and 65 other countries.

There is no easy solution to this problem. For many of us, it’s a matter of keeping our diabetes under control while we have a cure. In the developing world, however, many people die because they don’t have access to the basic tools to manage the condition. If a cure is important for everyone with D, it is even more needed for people in vulnerable situations.

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